Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency

Abstract Background The persistence of latent HIV-1 reservoirs is the principal barrier preventing the eradication of HIV-1 infection in patients by current antiretroviral therapy.It is thus crucial to understand the molecular mechanisms involved in the establishment, maintenance and reactivation of HIV-1 latency.Since chromatin remodeling has been

read more

Interpreting COVID-19 and Virtual Care Trends: Cohort Study

BackgroundThe coronavirus disease (COVID-19) pandemic is rapidly spreading across the world.As of March 26, 2020, there are more than 500,000 cases and more than 25,000 deaths related to COVID-19, and the numbers are increasing by the hour.ObjectiveThe aim of this study was to explore the trends in confirmed COVID-19 cases in North Carolina, and to

read more

A Two-Step Estimation Method for a Time-Varying INAR Model

This paper proposes a new time-varying integer-valued autoregressive (TV-INAR) model with a state vector following a logistic regression structure.Since the autoregressive coefficient in the model is Undercounter Freezers time-dependent, the Kalman-smoothed method is applicable.Some statistical properties of the model are established.To estimate th

read more